Condition: Community-acquired Pneumonia · Sponsor: Hellenic Institute for the Study of Sepsis
The primary objective of the REACT randomized clinical trial (RCT) is to optimize the clinical benefit from adjunctive clarithromycin treatment shown in the ACCESS trial and to provide evidence for the clinical benefit of early start of adjunctive oral clarithromycin guided by suPAR to prevent the progression into sepsis in patients with community-acquired pneumonia (CAP) at risk. This can be achieved by endpoints incorporating clinical benefit with the effect of treatment on the improvement of the immune dysregulation of CAP. The secondary objectives of REACT are to investigate the impact of early adjunctive treatment with clarithromycin on the resolution of CAP at the test-of-cure (TOC) visit.
This description comes directly from the study's public registry record.
Evangelos J Giamarellos-Bourboulis, MD, Phd · 2105831994 · egiamarel@med.uoa.gr
Athanasia Chatzianastasiou, Phd · 6938262747 · n.chatzianastasiou@sepsis.gr
Always discuss trial participation with your own doctor first.
| 5th Pulmonary Department, SOTIRIA Athens General Hospital of Chest Diseases | Athens, Athens, Greece | Recruiting |
| 1st Department of Internal Medicine - General Hospital of Athens "Sismanogleio-Amalia Fleming" | Athens, Greece, Greece | Not Yet Recruiting |
| 1st Department of Internal Medicine, AHEPA University General Hospital of Thessaloniki | Athens, Greece, Greece | Recruiting |
| 1st Department of Internal Medicine, EVANGELISMOS Athens General Hospital | Athens, Greece, Greece | Recruiting |
| 1st Department of Internal Medicine, G. GENNIMATAS Athens General Hospital | Athens, Greece, Greece | Recruiting |
| 1st Department of Internal Medicine, General University Hospital of Ioannina | Athens, Greece, Greece | Recruiting |
| 1st Department of Internal Medicine, KORGIALENEIO-BENAKEIO E.E.S. Athens General Hospital | Athens, Greece, Greece | Recruiting |
| 1st Department of Internal Medicine, THRIASIO General Hospital of Elefsis | Athens, Greece, Greece | Recruiting |
| 1st University Department of Pulmonary Medicine, SOTIRIA General Hospital of Chest Diseases of Athens | Athens, Greece, Greece | Recruiting |
| 2nd Department of Internal Medicine, Attikon University Hospital | Athens, Greece, Greece | Recruiting |
| 2nd Department of Internal Medicine, THRIASIO General Hospital of Elefsis | Athens, Greece, Greece | Recruiting |
| 2nd Department of Internal Medicine, TZANEIO Piraeus General Hospital | Athens, Greece, Greece | Recruiting |
+ 12 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT06294600