Condition: Prostate Cancer · Prostate Adenocarcinoma · Prostate Neoplasm · Sponsor: Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Evaluate the protein expression of lactate dehydrogenase enzyme (LDHA) and MCT-1/-4 transporters, involved in lactate synthesis and transport, in prostate carcinoma tissues from severely overweight/obese (BMI \> 27.5) and non-severely overweight/normoweight (BMI \< 27.5) patients affected by prostate carcinoma. ii. Characterize the immune infiltrate in the prostate carcinoma of the aforementioned patients. iii. Assess the association between intra-tumoral lactate accumulation (using LDHA and MCT-4 protein expression levels as readouts) and alterations in the tumor immune microenvironment and/or deregulation of relevant oncogenic pathways.
This description comes directly from the study's public registry record.
Giancarlo Albo, MD, · 00390255034501 · giancarlo.albo@policlinico.mi.it
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| IRCCS Cà Granda Ospedale Maggiore Policlinico Milano | Milan, Italy | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06292897