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Study identifier: NCT06291935 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Safety and Tolerability of Intravitreal Administration of VG901 in Patients With Retinitis Pigmentosa Due to Mutations in the CNGA1 Gene

Condition: Retinitis Pigmentosa  ·  Sponsor: VeonGen Therapeutics GmbH

PhasePhase 1
Planned participants6
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The goal of this phase 1 clinical trial is to learn about the safety and efficacy of a gene therapy, VG901, in patients with a rare disorder of the eye called Retinitis Pigmentosa. The main questions the study aims to answer are: * What is the best tolerated dose and are there any side effects, in particular any inflammatory reactions post drug administration? * Are there any early signs of efficacy on visual function? Participants will be administered a single intravitreal dose of VG901 into the most affected eye through a syringe and followed up for a year to monitor safety and efficacy. There will be two cohorts of participants in this study. Study Cohort 1 will receive the low dose and Study Cohort 2 will receive the high dose as specified in the Protocol.

This description comes directly from the study's public registry record.

Talk to the study team

Andrea Rindtorff  ·  +49 7071 29 87747  ·  andrea.rindtorff@med.uni-tuebingen.de

Always discuss trial participation with your own doctor first.

Locations (1)

Center for Ophthalmology, University of TuebingenTübingen, GermanyRecruiting

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Source record: clinicaltrials.gov/study/NCT06291935