Condition: Pemphigoid, Benign Mucous Membrane · Gingivitis Hyperplastic · Sponsor: Centre Hospitalier Universitaire de Nice
Patients suffering from Mucous Membrane Pemphigoid with desquamative gingivitis (MMPg) generally present a more degraded periodontal condition compared with controls. Bullous disease could represent a risk factor for plaque-induced periodontal disease, and vice versa. Indeed, the dysbiotic periodontal microbiota could aggravate the gingival damage specific to MMP, either directly by activating inflammatory pathways, or indirectly by degrading cellular and matrix components. On the other hand, areas of erosive gingiva generated by the autoimmune process could increase the virulent power of periodontal pathobionts, by representing accessible, nutrient-rich connective surfaces. Moreover, in recent years, bacterial studies based on a high-throughput metagenomic approach have suggested the existence of a relationship between the oral and intestinal microbiota in patients with degraded periodontal conditions and suffering from autoimmune inflammatory diseases (inflammatory bowel disease, acute graft-versus-host disease). This relationship can also be envisaged in MMPg patients who meet the conditions that allow this type of pathological process to occur: autoimmune disease; disruption of the gingival epithelial barrier in erosive gingival areas (increasing the risk of antigen exposure); large amounts of thick plaque; degraded periodontal condition with the presence of numerous periodontal pockets from which periodontopathogenic bacteria can translocate intra-tissularly and cause d…
This description comes directly from the study's public registry record.
Sophie DRIDI, PUPH · 04 92 03 30 07 · dr.sm.dridi@free.fr
rachida YATIMI · 04 92 03 30 07 · yatimi.r@chu-nice.fr
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| Nice University Hospital | Nice, France | Recruiting |
| Paris hospital Pitié Salpetrière (APHP) | Paris, France | Recruiting |
| Paris hospital Bretonneau (APHP) | Paris, France | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06291350