Condition: Extensive Stage Lung Small Cell Carcinoma · Stage IV Lung Cancer AJCC v8 · Sponsor: National Cancer Institute (NCI)
This phase I/II trial tests the safety, side effects, and best dose of iadademstat when given together with atezolizumab or durvalumab, and studies the effect of the combination in treating patients with small cell lung cancer that has spread outside of the lung in which it began or to other parts of the body (extensive stage) who initially received standard of care chemotherapy and immunotherapy. Iadademstat may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Immunotherapy with monoclonal antibodies, such as atezolizumab or durvalumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Adding iadademstat to either atezolizumab or durvalumab may be able to stabilize cancer for longer than atezolizumab or durvalumab alone in treating patients with extensive stage small cell lung cancer.
This description comes directly from the study's public registry record.
Contact details are listed per location below or on the registry record.
Always discuss trial participation with your own doctor first.
| City of Hope Comprehensive Cancer Center | Duarte, California, United States | Recruiting |
| City of Hope at Irvine Lennar | Irvine, California, United States | Recruiting |
| UC San Diego Moores Cancer Center | La Jolla, California, United States | Recruiting |
| University of California Davis Comprehensive Cancer Center | Sacramento, California, United States | Recruiting |
| Smilow Cancer Hospital Care Center at Saint Francis | Hartford, Connecticut, United States | Suspended |
| Yale University | New Haven, Connecticut, United States | Recruiting |
| Yale-New Haven Hospital North Haven Medical Center | North Haven, Connecticut, United States | Recruiting |
| Smilow Cancer Hospital Care Center at Long Ridge | Stamford, Connecticut, United States | Suspended |
| Smilow Cancer Hospital Care Center-Trumbull | Trumbull, Connecticut, United States | Recruiting |
| MedStar Georgetown University Hospital | Washington D.C., District of Columbia, United States | Recruiting |
| UF Health Cancer Institute - Gainesville | Gainesville, Florida, United States | Recruiting |
| Moffitt Cancer Center | Tampa, Florida, United States | Suspended |
+ 31 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT06287775