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Study identifier: NCT06287541 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

The Necessity of a Second Transurethral Resection in High-risk Non-muscle-invasive Bladder Cancer Patients With Negative Urine Biomarker After Initial Transurethral Resection

Condition: Non Muscle Invasive Bladder Cancer  ·  Sponsor: The First Affiliated Hospital with Nanjing Medical University

PhaseNA
Planned participants428
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The goal of this clinical trial is to evaluate the efficacy of using a urine biomarker test to guide the decision-making process regarding the necessity of reTURBT in NMIBC patients. The main question aims to answer whether patients with negative urine biomarker tests can safely avoid reTURBT without compromising recurrence-free survival. Participants who have completed the initial TURBT and tested negative for the urine biomarker will be enrolled in the study. They will then be randomized 1:2 into two groups:Group A: Participants will not receive reTURBT and Group B: Participants will undergo reTURBT. Researchers will compare the RFS rates between Group A (no reTURBT) and Group B (reTURBT) to determine if the urine biomarker test can safely spare patients from unnecessary reTURBT.

This description comes directly from the study's public registry record.

Talk to the study team

Qiang Lv, Ph.D  ·  doctorlvqiang@sina.com

Always discuss trial participation with your own doctor first.

Locations (1)

The First Affiliated Hospital of Nanjing Medical UniversityNanjing, Jiangsu, ChinaRecruiting

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Source record: clinicaltrials.gov/study/NCT06287541