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Study identifier: NCT06286397 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Topical Anti-Androgens in Pilonidal Sinus Disease

Condition: Pilonidal Disease · Pilonidal Disease of Natal Cleft · Pilonidal Sinus  ·  Sponsor: University of Pennsylvania

PhasePhase 2
Planned participants75
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The goal of this randomized clinical trial is to test the topical drug clascoterone in patients with pilonidal disease, which is a common, benign skin condition of the gluteal cleft. The main questions it aims to answer are: * Does clascoterone improve the severity of pilonidal disease as scored by a physician? * Does clascoterone improve patient symptoms due to pilonidal disease? * Does clascoterone improve the inflammation seen under the microscope in pilonidal disease removed at surgery Participants will apply clascoterone or a placebo cream to the diseased area for 3 months. They will be assessed every 4 weeks for disease severity assessed by a physician viewing patient photos and a symptom-based survey. Researchers will compare participants who received clascoterone treatment to those who received placebo.

This description comes directly from the study's public registry record.

Talk to the study team

Lillias Maguire, MD  ·  215-662-2078  ·  lillias.maguire@pennmedicine.upenn.edu

Always discuss trial participation with your own doctor first.

Locations (1)

University of PennsylvaniaPhiladelphia, Pennsylvania, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06286397