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Study identifier: NCT06282575 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Efficacy and Safety of Zanidatamab With Standard-of-care Therapy Against Standard-of-care Therapy for Advanced HER2-positive Biliary Tract Cancer

Condition: Biliary Tract Cancer  ·  Sponsor: Jazz Pharmaceuticals

PhasePhase 3
Planned participants286
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The purpose of this study is to evaluate the efficacy and safety of Zanidatamab plus CisGem (Cisplatin and Gemcitabine) with or without the addition of a programmed death protein 1/ligand-1 (PD-1/L1) inhibitor (physician's choice of either Durvalumab or Pembrolizumab, where approved under local regulations) as first line of treatment for participants with human epidermal growth factor receptor 2 (HER2)-positive biliary tract cancer.

This description comes directly from the study's public registry record.

Talk to the study team

Clinical Trial Disclosure & Transparency  ·  215-832-3750  ·  ClinicalTrialDisclosure@JazzPharma.com

Always discuss trial participation with your own doctor first.

Locations (185)

City of Hope(City of Hope National Medical Center, City of Hope Medical Center)Duarte, California, United StatesRecruiting
Rocky Mountain Cancer Centers, LLPLone Tree, Colorado, United StatesWithdrawn
AdventHealth Hematology and OncologyOrlando, Florida, United StatesRecruiting
Winship Cancer InstituteAtlanta, Georgia, United StatesRecruiting
The University of Kansas Cancer Center - WestwoodWestwood, Kansas, United StatesWithdrawn
Norton Cancer Institute - AudubonLouisville, Kentucky, United StatesRecruiting
Ochsner Clinic FoundationNew Orleans, Louisiana, United StatesRecruiting
Tufts Medical CenterBoston, Massachusetts, United StatesActive Not Recruiting
University of Michigan HospitalAnn Arbor, Michigan, United StatesRecruiting
Henry Ford Health SystemDetroit, Michigan, United StatesRecruiting
Minnesota Oncology Hematology, P.A.Maple Grove, Minnesota, United StatesActive Not Recruiting
Atlantic Health System/Morristown Medical CenterMorristown, New Jersey, United StatesActive Not Recruiting

+ 173 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06282575