Condition: Pediatric HIV Infection · Latent Tuberculosis · Sponsor: Brigham and Women's Hospital
Tuberculosis (TB) is the leading cause of death among children living with HIV, yet insufficient data are available on the pharmacokinetics of newer TB prevention strategies in children. Short-course TB prevention/latent TB infection (LTBI) treatment regimens increase completion rates but have not been adequately studied among children living with HIV. Our prospective, open-label PK study will examine and extend use of weekly rifapentine and isoniazid (3HP) among children receiving dolutegravir. This will address gaps in knowledge by examining two-way PK of short-course LTBI treatment in a vulnerable pediatric population.
This description comes directly from the study's public registry record.
Holly Rawizza, MD, MPH · 617-432-4686 · hrawizza@bwh.harvard.edu
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| University College Hospital | Ibadan, Oyo State, Nigeria | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06281834