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Study identifier: NCT06280872 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Physiologically Based Cord Clamping To Improve Neonatal Outcomes In Moderate And Late Preterm Newborns

Condition: Premature Birth · Respiratory Distress Syndrome in Premature Infant · Sepsis  ·  Sponsor: Queen Fabiola Children's University Hospital

PhaseNA
Planned participants180
Who can joinAll sexes, 32 Weeks to 36 Weeks
Healthy volunteersNo

About this study

Before birth, the baby's lungs are filled with fluid and babies do not use the lungs to breathe, as the oxygen comes from the placenta. As delivery approaches, the lungs begin to absorb the fluid. After vaginal delivery, the umbilical cord is clamped and cut after a delay that allows some of the blood in the umbilical cord and placenta to flow back into the baby. Meanwhile, as the baby breathes for the first time, the lungs fill with air and more fluid is pushed out. However, it does not always work out that way. A baby born prematurely may have breathing problems because of extra fluid staying in the lungs related to the immaturity of the lung structure. Thus, the baby must breathe quicker and harder to get enough oxygen enter into the lungs. The newborn is separated from the mother to provide emergency respiratory support. Although the baby is usually getting better within one or two days, the treatment requires close monitoring, breathing help, and nutritional help as the baby is too tired to suck and swallow milk. Sometimes, the baby cannot recover well and show greater trouble breathing needing intensive care. This further separates the mother and her baby. A possible mean to help the baby to adapt better after a premature birth while staying close to the mother is to delay cord clamping when efficient breathing is established, either spontaneously or after receiving breathing help at birth. In this study, we intend to test this procedure in moderate or late preterm inf…

This description comes directly from the study's public registry record.

Talk to the study team

Anna AMORUSO  ·  +3224773250  ·  anna.amoruso@hubruxelles.be

Andrew CARLIN  ·  +3224773295  ·  andrew.carlin@chu-brugmann.be

Always discuss trial participation with your own doctor first.

Locations (2)

CHU BrugmannBrussels, BelgiumRecruiting
Hôpital Universitaire Des Enfants Reine FabiolaBrussels, BelgiumRecruiting

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Source record: clinicaltrials.gov/study/NCT06280872