Condition: Multiple Sclerosis · Sponsor: Assistance Publique - Hôpitaux de Paris
The Service Hospitalier Frédéric-Joliot (SHFJ) and Paris Brain Institute (ICM) groups have identified \[18F\]-DPA-714 as a promising second-generation TSPO tracer, a macromolecule overexpressed in neuroinflammatory conditions, for PET imaging. They have also developed a non-invasive quantification methodology, enabling the generation of individual neuroinflammation maps in MS patients. Recent findings from \[18F\]-DPA-714 PET imaging in MS patients revealed that most of the white matter lesions contained a smoldering component, even when considered inactive on MRI, and that their neuroinflammatory profiles were associated with longitudinal disability worsening. The Inflanet project aims to leverage a unique consortium comprising French radiochemists, radiopharmacists, nuclear medicine/neuroimaging experts, and MS neurologists to establish the first national network dedicated to \[18F\]-DPA-714 PET imaging in MS, so far limited to monocentric studies. The objectives of the INFLANET project are (1) to conduct the first multicenter study assessing neuroinflammation in patients with active MS using \[18F\]DPA-714 PET tracer, and (2) to establish a methodology suitable for the quantification of multicenter PET data obtained with \[18F\]DPA-714. The INFLANET initiative aims to disseminate TSPO PET within the French MS research community, thereby opening the unique perspective of future large-scale, multicenter studies. These endeavors are expected to enhance our capacity to predic…
This description comes directly from the study's public registry record.
Bruno Stankoff, MD · 0171970659 · bruno.stankoff@aphp.fr
Always discuss trial participation with your own doctor first.
| Département de Neurologie,Pierre Wertheimer Neurological Hospital | Lyon, France | Recruiting |
| CERMEP | Lyon, France | Recruiting |
| CIC Neurosciences, GH Pitié-Salpêtrière | Paris, France | Recruiting |
| Centre Eugène Marquis | Rennes, France | Not Yet Recruiting |
| Service de Neurologie, CHU Pontchaillou | Rennes, France | Not Yet Recruiting |
| CHU Toulouse - Département de Neurologie | Toulouse, France | Not Yet Recruiting |
| CHU Toulouse - Service de médecine nucléaire | Toulouse, France | Not Yet Recruiting |
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Source record: clinicaltrials.gov/study/NCT06280742