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Study identifier: NCT06279598 Synced from ClinicalTrials.gov · July 29, 2026
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PT-STRESS Study: Predicting Treatment Success and Dealing With Non-response in the Treatment of PTSD

Condition: Stress Disorders, Post-Traumatic  ·  Sponsor: University of Groningen

PhaseNA
Planned participants442
Who can joinAll sexes, 18 Years to 65 Years
Healthy volunteersNo

About this study

The aim of this study is to increase understanding of the effectiveness and efficiency of psychological treatment for adult patients with posttraumatic stress disorder -PTSD- and to make it more personalized. Key questions: 1. Which predictors of treatment success influence treatment outcome of patients with PTSD who receive the three psychotherapeutic treatments investigated in this study? 2. Which specific moderators can be identified with regard to the different psychotherapies (Eye Movement Desensitization and Reprocessing -EMDR-; Prolonged Exposure -PE-; and Interpersonal Psychotherapy -IPT- in the second phase)? 3. In patients with PTSD, does offering another proven effective form of trauma-focused psychotherapy (PE after EMDR, or EMDR after PE) improve symptoms following insufficient response to a first trauma-focused treatment? 4. Is switching from a trauma-focused therapy to a non-trauma-focused treatment (IPT) a more effective strategy for dealing with non-response to a first proven effective psychotherapeutic treatment compared to switching to another trauma-focused therapy? 5. Are there differences in treatment tolerance and differences in dropout rates between PE, EMDR and IPT? Secondary goals: * Investigating the extent to which therapist allegiance to a specific therapy method affects outcomes; * Investigating whether the quality of therapy implementation or the treatment integrity ('adherence/ competence') affects treatment outcomes; * Investigating how mu…

This description comes directly from the study's public registry record.

Talk to the study team

Maarten K van Dijk, PhD  ·  +31 0570-604000  ·  m.vandijk@dimence.nl

Dominique Jonkers, Master  ·  +31 038-4692300  ·  d.jonkers@dimence.nl

Always discuss trial participation with your own doctor first.

Locations (1)

DimenceDeventer, NetherlandsRecruiting

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Source record: clinicaltrials.gov/study/NCT06279598