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Study identifier: NCT06276491 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Phase 1, Safety and Tolerability Study of XmAb541 in Advanced Solid Tumors

Condition: Ovarian Cancer · Endometrial Cancer · Germ Cell Tumor  ·  Sponsor: Xencor, Inc.

PhasePhase 1
Planned participants282
Who can joinAll sexes, 15 Years to no upper limit
Healthy volunteersNo

About this study

The primary purpose of this study is to determine whether the investigational drug XmAb541 is safe and well tolerated, and to determine an optimal and safe dose(s) for further study. The study will also evaluate the effect of XmAb541 on tumor outcomes.

This description comes directly from the study's public registry record.

Talk to the study team

XmAb541-01 Central Contact  ·  info541-01@xencor.com

Always discuss trial participation with your own doctor first.

Locations (18)

City of HopeDuarte, California, United StatesRecruiting
StanfordPalo Alto, California, United StatesRecruiting
University of CaliforniaSan Francisco, California, United StatesRecruiting
Moffitt Cancer CenterTampa, Florida, United StatesRecruiting
Winship Cancer Institute, Emory UniversityAtlanta, Georgia, United StatesRecruiting
University of Chicago Medical CenterChicago, Illinois, United StatesRecruiting
Indiana University Melvin and Bren Simon Comprehensive Cancer CenterIndianapolis, Indiana, United StatesRecruiting
Karmanos Cancer InstituteDetroit, Michigan, United StatesRecruiting
University of MinnesotaMinneapolis, Minnesota, United StatesRecruiting
The John Theruer Cancer Center at Hackensack University Medical CenterHackensack, New Jersey, United StatesRecruiting
Icahn School of Medicine at Mount SinaiNew York, New York, United StatesRecruiting
Montefiore Einstein Comprehensive Cancer CenterThe Bronx, New York, United StatesRecruiting

+ 6 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06276491