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Study identifier: NCT06272812 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

A Study to Evaluate the Efficacy, Safety and Immunogenicity of MTBVAC in Adolescents and Adults Living in a TB Endemic Region.

Condition: Tuberculosis (TB)  ·  Sponsor: International AIDS Vaccine Initiative

PhasePhase 2
Planned participants5500
Who can joinAll sexes, 14 Years to 45 Years
Healthy volunteersYes

About this study

A Phase 2b, double-blind, randomized, placebo-controlled study to evaluate the efficacy, safety and immunogenicity of a candidate tuberculosis (TB) vaccine, MTBVAC, against TB disease in adolescents and adults aged 14-45 years, living in a TB endemic region.

This description comes directly from the study's public registry record.

Talk to the study team

Elana Van Brakel, MD  ·  27.21.344.1200  ·  evanbrakel@iavi.org

Ansuya Naidoo, MBChB  ·  +27724152138  ·  ANaidoo@iavi.org

Always discuss trial participation with your own doctor first.

Locations (16)

Victoria Biomedical Research InstituteKisumu, KenyaRecruiting
Kenya Medical Research InstituteNairobi, KenyaRecruiting
JOSHA ResearchBloemfontein, South AfricaRecruiting
South African Tuberculosis Vaccine InitiativeCape Town, South AfricaRecruiting
TASK Applied Science Pty Ltd. TASK DelftCape Town, South AfricaRecruiting
UCTLI CLII - Centre for Lung Infection and ImmunityCape Town, South AfricaRecruiting
University of Cape Town Lung Institute PtyLtd. Centre for Tuberculosis Research InnovationCape Town, South AfricaRecruiting
Wellcome Centre for Infectious Diseases Research in AfricaCape Town, South AfricaRecruiting
Synergy Biomedical Research InstituteEast London, South AfricaRecruiting
TASK Eden Pty Ltd.George, South AfricaRecruiting
Perinatal HIV Research UnitJohannesburg, South AfricaRecruiting
Be Part Research Pty Ltd.Paarl, South AfricaRecruiting

+ 4 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06272812