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Study identifier: NCT06271941 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Reducing Neoplasia Recurrence After Endoscopic Resection of Large Colorectal Polyps

Condition: Colorectal Cancer · Polyp of Colon  ·  Sponsor: Centre hospitalier de l'Université de Montréal (CHUM)

PhaseNA
Planned participants892
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

Large (≥20mm) colorectal polyps often harbor areas of advanced neoplasia, making them immediate colorectal cancer (CRC) precursors. Such polyps have to be completely removed to prevent CRC and to avoid surgery and/or adjuvant therapy. The laterally spreading lesions (LSLs) are removed via endoscopic mucosal resection (EMR). However, recurrence is common. New techniques for LSL resection (hybrid argon plasma coagulation (h-APC) margin and base ablation) have shown a reduction in recurrence following the interventions. We hypothesize that performing hybrid argon plasma coagulation (h-APC) margin and base ablation during EMR of large (≥20mm) colorectal LSLs will lead to lower rates of lesion recurrence compared to Snare tip soft coagulation (STSC) margin ablation.

This description comes directly from the study's public registry record.

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Locations (1)

Centre Hospitalier de l'Université de MontréalMontreal, Quebec, CanadaRecruiting

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Source record: clinicaltrials.gov/study/NCT06271941