Condition: Epilepsy in Children · Sponsor: University Hospital, Angers
This study investigates the usefulness of high resolution electrical source imaging (HR-ESI) in the setting of presurgical evaluation of drug-resistant focal epilepsy in children. This method is based on an estimation of the intra-cerebral source that produces a signal recorded by scalp electrodes by solving the inverse problem, taking into account attenuation factors resulting from particular conductivity properties of the cerebral, peri-cerebral and cranial tissues. Electrical sources are then fused on structural magnetic resonance imaging (MRI). Scalp EEG recorded using 64 to 256 electrodes refers to as high resolution EEG (HR-EEG), leading to HR-ESI. Studies based on small population of children or on mixt population of children and adults showed that HR-ESI has accuracy values, i.e. percentage of true positives (electrical source localized in the brain area resected and success of surgery) and true negatives (electrical source localized outside the brain area resected and failure of surgery) among the total population, ranging from 50 to 80%. Discrepancies between studies could be explained by the limited number of patients included or by the mixture of pediatric and adult data. Another limitation of previously published studies is that the spatial pattern of dipole source distribution was not taken into account to determine prediction accuracy of ESI. Studies using magnetoencephalography (MEG) to perform magnetic source imaging (MSI) suggest that the spatial patt…
This description comes directly from the study's public registry record.
Patrick Van Bogaert, Professor · +33 2 41 35 48 46 · Patrick.VanBogaert@chu-angers.fr
Always discuss trial participation with your own doctor first.
| Angers university hospital, Pédiatric department | Angers, France | Recruiting |
| Lille University Hospital, Clinical Neurophysiology Department | Lille, France | Not Yet Recruiting |
| Civil Hospices of Lyon, Functional Neurology Department | Lyon, France | Not Yet Recruiting |
| Marseille Timone University Hospital, Epileptology and Cerebral Rhythmology Department | Marseille, France | Not Yet Recruiting |
| Nancy University Hospital, Neurology Department | Nancy, France | Not Yet Recruiting |
| Paris Neck University Hospital, Pediatric department | Paris, France | Not Yet Recruiting |
| Paris Robert-Debré University Hospital, Department of Physiology, Pediatric functional explorations | Paris, France | Not Yet Recruiting |
| Rothschild Ophtalmologic Fondation, Pediatric neurosurgery Department | Paris, France | Not Yet Recruiting |
| Rennes University Hospital, Pediatric department | Rennes, France | Not Yet Recruiting |
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Source record: clinicaltrials.gov/study/NCT06271785