Condition: Infantile Spasm · Sponsor: Assistance Publique - Hôpitaux de Paris
Infantile spasms are defined by the occurrence of epileptic episodes characterized by the appearance of very specific motor seizures, made up of rapid, repeated contractions in flexion or extension known as spasms. This syndrome is of high concern as it will lead to mental retardation if it is not early identified and treated. Most often, spasms are characterized by sudden contractions of the body in flexion. More rarely, spasms occur in extension: the neck and legs suddenly tense, and the arms move upwards or sideways. Spasms may be accompanied by eye revulsion. They are brief, lasting 0.5 to 2 seconds each. At the start of the attack, they may be isolated, but then may occur in series lasting up to several tens of minutes. Because of its nature and duration, infantile spasm is often difficult to identify and is often confused with benign motor manifestations in children, such as hiccups or muscular jerks. This difficulty often leads to delays in diagnosis. Indeed, patients are often seen at the stage when cognitive regression has set in. The gold standard for diagnosing infantile spasms is to capture them on video-EEG to confirm the ictal correlate of the seizure. Although multiple variations are known, the ictal correlation is often a diffuse slow wave of high amplitude with subsequent electrodecrement. Yet continuous video electroencephalogram is an expensive and time-consuming resource often unavailable in developing countries and in many parts of the developed world. F…
This description comes directly from the study's public registry record.
Samuel Diop, PhD · + 33 1 47 10 79 00 · snfdiop@outlook.com
Jean Bergounioux, MD, PhD · + 33 1 47 10 79 00 · jean.bergounioux@aphp.fr
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| Department of paediatric neurological care and intensive care unity (PICU), Raymond Poincaré hospital - APHP | Garches, France | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06266234