Condition: Benign Prostatic Hyperplasia With Outflow Obstruction · Lower Urinary Tract Obstructive Syndrome · Sponsor: Marmara University
Histologically, BPH is a benign proliferative process involving both epithelial and stromal elements and is characterised by progressive enlargement of the prostate. Symptom complex including increased frequency of urination, sudden feeling of urge to urinate, nocturia, difficulty in urinating, feeling of incomplete emptying of the bladder, decreased flow rate and intermittent urination are called lower urinary tract symptoms (LUTS). The most important cause of LUTS in men is BPH. Many structural and physiological changes occur in the lower urinary system with bladder outlet obstruction. Detrusor hypertrophy and bladder hyperactivity may occur due to bladder outlet obstruction. Although the density of afferent and efferent nerves in the bladder decreases after urethral obstruction, enlargement of their trunks indicates that changes occur in these nerves. In addition, changes also occur in the neural pathways of the central nervous system following lower urinary tract obstruction. Nerve growth factor (NGF) and brain derived neurotropin factor (BDNF) are trophic proteins that act as retrograde messengers between peripheral effector tissue and the nerves that innervate it. In peripheral tissues, the source of NGF and BDNF is presumed to be the target tissues innervated by nerves. Smooth muscle cells, fibroblasts, astrocytes and other cells synthesise NGF and BDNF in culture medium. Many potential stimuli that increase NGF in the lower urinary system have been identified. These a…
This description comes directly from the study's public registry record.
Haydar Kamil ÇAM, Prof. Dr. · +905323259547 · kamilcam@hotmail.com
Kader Ada Doğan, MD · +905323845598 · kader.dogan11@gmail.com
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| Marmara University Hospital | Istanbul, Turkey (Türkiye) | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06265519