Condition: Limbal Stem Cell Deficiency · Sponsor: University Hospital, Montpellier
Objectives The transparent surface of the eye, called the cornea, plays a crucial role in transmitting light to the retina and in protecting the eye. On its external surface, the cornea is composed of a constantly renewing multistratified epithelium. This mechanism is fueled by stem cells located in the limbus (the transition zone between the cornea and the sclera). Limbal Stem Cell Deficiency (LSCD) is characterized by a decrease or cessation of epithelial renewal and neovascularization of the cornea. Consequently, the cornea loses its integrity and transparency. This visually impairing condition is currently in a therapeutic impasse as only autologous limbal or allogeneic corneal grafts are viable options, but they pose significant risks to patients. Studies have shown that the oral cavity contains stem cells that can be isolated, cultured, and transdifferentiated into limbal stem cells (LSCs). However, to date, these studies are limited, and no protocol has been validated. In this study, the advantage of the accessibility of the oral cavity is used to develop a protocol for differentiating cells from the oral mucosa into limbal stem cells (LSCs) for use in a future clinical trial with patients. Methodology This prospective monocentric study will be conducted on patients from the ophthalmology department of the Montpellier University Hospital who have an indication for conjunctival reconstruction. After obtaining consent from the patients, cells from the oral wall will be…
This description comes directly from the study's public registry record.
Vincent Daien, MD PhD · 04 67 33 69 66 · v-daien@chu-montpellier.fr
Hannah Crowdy · 04 67 33 79 62 · h-crowdy@chu-montpellier.fr
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| CHU Gui de Chauliac - Service d'Ophtamologie | Montpellier, Occitanie, France | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06265298