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Study identifier: NCT06264700 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Applying Directly Observed Therapy to Hydroxyurea to Realize Effectiveness

Condition: Sickle Cell Disease  ·  Sponsor: Nationwide Children's Hospital

PhaseNA
Planned participants60
Who can joinAll sexes, 11 Years to no upper limit
Healthy volunteersNo

About this study

This study is for caregivers of young children with sickle cell disease and adolescents with sickle cell disease who are currently prescribed hydroxyurea and are receiving care at one of the study sites. The study will assess retention and engagement during a pilot randomized control trial comparing video directly observed therapy (VDOT) to attention control. We also hope to understand more about patient and family preferences longer-term adherence monitoring and intervention. Participants will use an electronic adherence monitor (provided by the study team) to measure how often they are taking their hydroxyurea. Participants will also be asked to complete questionnaires throughout the study period to provide information about their expectations for, experience with, and satisfaction with the study materials.

This description comes directly from the study's public registry record.

Talk to the study team

Susan Creary, MD, MSc  ·  (614) 722-3550  ·  susan.creary@nationwidechildrens.org

Nate Goldfarb, MPH  ·  (614) 965-4948  ·  nate.goldfarb@nationwidechildrens.org

Always discuss trial participation with your own doctor first.

Locations (3)

Lurie Children's HospitalChicago, Illinois, United StatesNot Yet Recruiting
Nationwide Children's HospitalColumbus, Ohio, United StatesRecruiting
Hasbro Children's HospitalProvidence, Rhode Island, United StatesNot Yet Recruiting

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Source record: clinicaltrials.gov/study/NCT06264700