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Study identifier: NCT06263543 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Sequencing Antibody Drug Conjugates in ER+/HER2 LOW/ULTRA LOW MBC

Condition: Breast Cancer · Metastatic Breast Cancer · Advanced Breast Cancer  ·  Sponsor: Reshma L. Mahtani, D.O.

PhasePhase 2
Planned participants75
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The purpose of this research study is to see if the medication sacituzumab govitecan (SG) is effective at the currently approved dose and schedule in people who have previously received trastuzumab deruxtecan (T-DXd) for the treatment of metastatic, hormone receptor positive (HR+)/human epidermal growth factor 2 low (HER2 low) breast cancer. Although SG is approved to treat metastatic HR+/HER2 negative breast cancer, the aim of this study is to determine if SG is still effective specifically in people who have already received T-DXd.

This description comes directly from the study's public registry record.

Talk to the study team

Reshma L Mahtani, D.O.  ·  (786) 596-2000  ·  rmahtani@baptisthealth.net

Krystal Fernandez  ·  (786) 596-2000  ·  krystal.fernandez@baptisthealth.net

Always discuss trial participation with your own doctor first.

Locations (3)

UCLA Jonsson Comprehensive Cancer CenterLos Angeles, California, United StatesNot Yet Recruiting
Miami Cancer Institute at Baptist Health, Inc.Miami, Florida, United StatesRecruiting
Winship Cancer Institute at Emory UniversityAtlanta, Georgia, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06263543