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Study identifier: NCT06263075 Synced from ClinicalTrials.gov · July 28, 2026
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Hemodynamic Monitoring During Craniosynostosis Surgery: Comparing Traditional and Newer Technology Monitors (CRASY-PRAM)

Condition: Craniosynostoses · Hypovolemia · Hemorrhage  ·  Sponsor: IRCCS Azienda Ospedaliero-Universitaria di Bologna

PhaseN/A
Planned participants30
Who can joinAll sexes, 3 Months to 8 Months
Healthy volunteersNo

About this study

Hemodynamic evaluation during pediatric anesthesia is essential to care management. Intraoperative cardiovascular instability is frequent in major surgeries, and appropriate monitoring is necessary to ensure safe anesthetic conduction and promptly detect changes in blood pressure, cardiac output, blood volume, and organ perfusion. In this context, advanced hemodynamic monitoring, continuous measuring, and estimating various parameters can allow a more specific hemodynamic profile and help identify the causal mechanisms of its variability. Moreover, the reference ranges of hemodynamic values in different pediatric ages and how to best monitor hemodynamic status in pediatrics are still debated. Surgical treatment of craniosynostosis is usually performed at an early age, between 3 and 8 months of age. The operation is burdened by a high risk of hemodynamic instability related mainly, but not only, to potential substantial hemorrhagic losses. This study aims to characterize the hemodynamic events occurring during corrective craniosynostosis surgery, recorded simultaneously with standard monitoring and Pressure Recording Analytic Method (PRAM), and to analyze the paired measurements.

This description comes directly from the study's public registry record.

Talk to the study team

Maria Cristina Mondardini, MD  ·  051 2143650  ·  mariacristina.mondardini@aosp.bo.it

Fabio Caramelli, MD  ·  fabio.caramelli@aosp.bo.it

Always discuss trial participation with your own doctor first.

Locations (1)

IRCCS AOU of Bologna Policlinico Sant'OrsolaBologna, BO, ItalyRecruiting

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Source record: clinicaltrials.gov/study/NCT06263075