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Study identifier: NCT06262438 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

CHIP-AML22/Quizartinib: Quizartinib + Chemotherapy in Newly Diagnosed Pediatric FLT3-ITD+ and NPM1wt AML Patients

Condition: Acute Myeloid Leukemia in Children  ·  Sponsor: Princess Maxima Center for Pediatric Oncology

PhasePhase 2
Planned participants60
Who can joinAll sexes, 1 Month to 18 Years
Healthy volunteersNo

About this study

The CHIP-AML22 Master protocol has the overall aim of increasing the cure rate in newly diagnosed pediatric de novo AML patients, while avoiding unnecessary toxicity. The linked Quizartinib trial (CHIP-AML22/Quizartinib) is a phase II, single arm, open label, study on the safety, efficacy, pharmacokinetics and pharmacodynamics of quizartinib in combination with chemotherapy and as single-agent after high dose therapy in newly diagnosed pediatric AML patients with a FLT3-ITD mutation and NPM1 wild-type.

This description comes directly from the study's public registry record.

Talk to the study team

Renske Benedictus  ·  +31 88 972 72 72  ·  CHIP-AML22@prinsesmaximacentrum.nl

Always discuss trial participation with your own doctor first.

Locations (1)

Princess Máxima Center for pediatric oncologyUtrecht, Utrecht, NetherlandsRecruiting

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Source record: clinicaltrials.gov/study/NCT06262438