Condition: Liver Transplant; Complications · Sponsor: Société Française d'Anesthésie et de Réanimation
Liver transplantation (LT) is a surgery with risk of bleeding. Several risk factors have been identified: complex dissection, portal hypertension, history of ascites fluid infections, history of surgical procedures, pre-existing complex hemostatic disorders and those acquired during the procedure. Diffuse bleeding can occur at any time during the 3 phases of surgery: dissection, anhepatic and neohepatic. However, intraoperative bleeding and transfusion requirements remain difficult to predict. Current predictive models are based in particular on preoperative characteristics and do not take into account the course and different phases of the operation. The need for transfusions has largely decreased over the last 20 years, and currently around 20-25% of patients are transfused (transfusion of at least 1 blood product during LT). However, massive transfusion is necessary in 10% of LT. The European Society of Anaesthesiology (ESA) has issued recommendations on the management of severe bleeding during surgery. However, these recommendations are not specific to LT. Moreover, transfusion strategies vary widely from one center to another. The implementation of protocols within teams dedicated to LT has led to a reduction in bleeding and transfusion, with or without the use of viscoelastic testing. Intraoperative bleeding and transfusion requirements, as well as postoperative thromboembolic complications, remain difficult to predict. Predictive models of bleeding risk have been dev…
This description comes directly from the study's public registry record.
Emmanuel WEISS, MD · +33 1 40 87 58 81 · emmanuel.weiss@aphp.fr
Stéphanie ROULLET, MD · +33 1 45 59 32 19 · stephanie.roullet@aphp.fr
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| Chru Minjoz | Besançon, France | Recruiting |
| CHU Estaing | Clermont, France | Not Yet Recruiting |
| Hôpital Beaujon | Clichy, France | Not Yet Recruiting |
| CHU Grenoble Alpes | Grenoble, France | Not Yet Recruiting |
| CHU Claude Huriez | Lille, France | Recruiting |
| Hôpital de la Croix-Rousse | Lyon, France | Recruiting |
| CHU La Timone | Marseille, France | Not Yet Recruiting |
| Hôpital St Eloi | Montpellier, France | Not Yet Recruiting |
| Hôpital De L'Archet 2 | Nice, France | Not Yet Recruiting |
| CHU Pitié-Salpêtrière | Paris, France | Not Yet Recruiting |
| CHU Haut Levêque | Pessac, France | Not Yet Recruiting |
| CHU Pontchaillou | Rennes, France | Not Yet Recruiting |
+ 4 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT06257407