Condition: Limited Stage Small Cell Lung Cancer · Sponsor: Shanghai Pulmonary Hospital, Shanghai, China
For limited-stage small cell lung cancer (SCLC), neoadjuvant chemotherapy plus PD-1 antibody is recommended. However, most patients cannot achieve a complete pathological response (CPR). A new immunotherapeutic strategy is needed to achieve a higher CPR rate. JS004 is a new antibody targeting B and T lymphocyte attenuator (BTLA), which restrains immune cells\' function and leads to immune escape of tumor cells. The combination of PD-1 and BTLA antibodies has shown a good therapeutic effect in solid tumors. This trial aims to investigate the efficacy and safety of the therapeutic regimen of toripalimab and JS004 plus etoposide and platinum Chemotherapy in limited-stage SCLC.
This description comes directly from the study's public registry record.
Peng Zhang, PhD · 02165115006 · zhangpeng1121@tongji.edu.cn
Tao Ge, PhD · sudagetao2017@163.com
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| Shanghai Pulmonary Hospital | Shanghai, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06256237