Condition: Crohn Disease · Sponsor: Massachusetts General Hospital
In this study twenty-five (25) subjects with Crohn's disease scheduled for possible surgical intervention will be recruited for this study and a PET/MR scan using the collagen-binding radiotracer will be performed. The study aims to establish the performance figures of PET/MR using \[68Ga\]CBP8-PET for preoperative detection and differentiation of strictures with a fibrotic component in patients with Crohn's disease by using surgical and histologic findings (when available) as the standard for comparison. Furthermore, the investigators will determine the performance figures with which strictures are identified and characterized by PET/MR using \[68Ga\]CBP8-PET compared to each modality in isolation (PET alone or MR alone). Blood and tissue markers for fibrostenosis will be explored (either predictive or as biomarkers for fibrotic burden), using histologic and molecular testing by using surgical and histologic findings (when available) as the standard for comparison. Lastly the investigators want to determine the performance figures with which strictures are identified and characterized by PET/MR using \[68Ga\]CBP8-PET compared to each modality in isolation (PET alone or MR alone).
This description comes directly from the study's public registry record.
Onofrio Catalano, MD, Ph.D · 617-724-4030 · ocatalano@mgh.harvard.edu
Diandrea Galloway · 617-643-1407 · dgalloway@mgh.harvard.edu
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| Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School | Charlestown, Massachusetts, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06252493