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Study identifier: NCT06251778 Synced from ClinicalTrials.gov · July 29, 2026
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NatiOnal Referral cenTEr Study of Transthyretin Amyloid Cardiomyopathy(ATTR) Patients on Tafamidis

Condition: Amyloidosis · Amyloidosis Cardiac · ATTR Amyloidosis Wild Type  ·  Sponsor: Paolo Milani

PhaseN/A
Planned participants200
Who can joinAll sexes, 18 Years to 99 Years
Healthy volunteersNo

About this study

All ATTRwt patients on tafamidis 61 mg treatment will be clinically evaluated before treatment initiation and subsequently every six months for the eligibility to continue tafamidis treatment, according to Italian Medicines Agency regulations. C onsidering the significant risk of developing heart rhythm disturbances due to cardiac amyloidosis, especially in transthyretin form (ATTRwt), in routine clinical practice a stricter heart rhythm monitoring is recommended in ATTRwt patients. Moreover, particular attention is usually paid for those who present atrio-ventricular and/or intraventricular block at the baseline electrocardiogram. Data about rhythm disturbances and diuretic dose need will be collected during the planned physical examination every six months and the Holter ECG monitoring requested by the physician at the end of every planned clinical evaluation.

This description comes directly from the study's public registry record.

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Locations (1)

Fondazione IRCCS Policlinico San MatteoPavia, ItalyRecruiting

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Source record: clinicaltrials.gov/study/NCT06251778