Condition: Benzodiazepine Adverse Reaction · Depression, Anxiety · Benzodiazepine Dependence · Sponsor: The First Affiliated Hospital of Dalian Medical University
This study explores the impact of long-term benzodiazepine (BZDs) use on cognitive function and associated neuroimaging markers. While BZDs are established treatments for conditions like anxiety and insomnia, recent warnings highlight risks, including neurocognitive effects. Neuroimaging studies indicate potential neuroprotective effects of BZDs. Functional near-infrared spectroscopy (fNIRS) measures cerebral cortex function during cognitive tasks. Combining fNIRS with mood and cognitive scales, this study assesses cortical activation. 2-deoxy-2-fluoro-D-glucose-positron emission tomography (FDG-PET) evaluates brain metabolism. DPA-714 PET assesses neuroinflammation. The primary objective is to compare brain functional activation, metabolism, and neuroinflammatory levels between long-term BZD users and non-users. This comprehensive approach aims to provide insights into BZD effects on cognition and associated brain markers.
This description comes directly from the study's public registry record.
Hui min Zhang · +86 18098876233 · huiminzhangxs@163.com
Mei chen Liu · +86 18098871637 · meichenliu9019@163.com
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| The First Affiliated Hospital of Dalian Medical University | Dalian, Liaoning, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06250842