Condition: Heart Failure With Preserved Ejection Fraction · End Stage Renal Disease on Dialysis · Sponsor: National Taiwan University Hospital
The presence of CKD has been linked to the development of HFpEF. Currently, the treatment for HFpEF is limited. SGLT2i are one of the few drug classes that have proven efficacy in HFpEF in randomized controlled trials. The results of mechanistic studies suggest that the benefits of SGLT2i on diastolic heart failure are independent of their glycosuric actions and may still be present in anuric subjects. Despite the significance of HFpEF in patients with CKD, patients with advanced kidney disease have been excluded from studies investigating anti-heart failure drugs. The effects of SGLT2i in patients under maintenance dialysis are largely unknown. Past pharmacokinetics and pharmacodynamics studies on empagliflozin in patients with end-stage renal disease (ESRD) demonstrated that the use of empagliflozin in patients with ESRD seemed safe, yet its efficacy remains to be explored.
This description comes directly from the study's public registry record.
Donna SH Lin, MD · +886912902379 · Donna.lin24@gmail.com
Hao-Yun Lo, MD · +886972234640 · limoonby@gmail.com
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| National Taiwan University Hospital Hsinchu Branch | Hsinchu, Taiwan | Recruiting |
| Shin Kong Wu Ho-Su Memorial Hospital | Taipei, Taiwan | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06249945