Condition: Preeclampsia · Sponsor: Ohio State University
The goal of this prospective observational cohort study of pregnant people at-risk of preeclampsia receiving aspirin as part of clinical care or a planned randomized controlled trial of 81mg vs. 162mg of aspirin is to generate proteomic data to show a distinct maternal and fetal Extracellular Vesicle (EV) proteome profile with aspirin treatment, and develop and validate a multi-marker panel for the monitoring of placental function in people at-risk of Preeclampsia and in response to aspirin treatment. The primary research question is: 1\. Does the maternal and fetal Positive for Placental Alkaline Phosphatase (PLAP+) Extracellular Vesicle (EV) proteome profile in the 2nd and 3rd trimester of pregnancy differ between people who receive aspirin and develop (or not) preeclampsia? Participants will be asked to give blood samples up to four times during and at the end of their pregnancy.
This description comes directly from the study's public registry record.
Maged Costantine, MD, MBA · 614-293-2222 · Maged.Costantine@osumc.edu
Kara Rood, MD · 614-293-8045 · Kara.Rood@osumc.edu
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| The Ohio State University Wexner Medical Center OB/GYN Maternal and Fetal Medicine | Columbus, Ohio, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06249178