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Study identifier: NCT06248606 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Adagrasib + SRS for Patients With Metastatic KRAS G12C-mutated NSCLC With Untreated Brain Metastases

Condition: Non Small Cell Lung Cancer · NSCLC · KRAS G12C  ·  Sponsor: Ryan Gentzler, MD

PhasePhase 2
Planned participants30
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This is a single arm phase 2 trial is to evaluate the efficacy of SRS plus adagrasib for the treatment of brain metastases for patients with KRAS G12C-mutated non-small cell lung cancer (NSCLC). A total of 30 patients will be enrolled on this study.

This description comes directly from the study's public registry record.

Talk to the study team

Ryan Gentzler, MD, MS  ·  434-924-4251  ·  rg2uc@uvahealth.org

Amber Ryba  ·  317-634-5842  ·  aryba@hoosiercancer.org

Always discuss trial participation with your own doctor first.

Locations (3)

Ohio State University Comprehensive Cancer CenterColumbus, Ohio, United StatesRecruiting
University of Virginia Health SystemCharlottesville, Virginia, United StatesRecruiting
Virginia Commonwealth UniversityRichmond, Virginia, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06248606