Condition: Recurrent Childhood Acute Myeloid Leukemia · Recurrent Childhood Myelodysplastic Syndrome · Recurrent Juvenile Myelomonocytic Leukemia · Sponsor: Children's Oncology Group
This phase I trial tests the safety, side effects, and best dose of imetelstat in combination with fludarabine and cytarabine in treating patients with acute myeloid leukemia (AML), myelodysplastic syndrome (MDS) or juvenile myelomonocytic leukemia (JMML) that has not responded to previous treatment (refractory) or that has come back after a period of improvement (recurrent). Imetelstat may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Chemotherapy drugs, such as fludarabine and cytarabine, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving imetelstat in combination with fludarabine and cytarabine may work better in treating patients with refractory or recurrent AML, MDS, and JMML.
This description comes directly from the study's public registry record.
Contact details are listed per location below or on the registry record.
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| Children's Hospital of Alabama | Birmingham, Alabama, United States | Recruiting |
| Children's Hospital of Orange County | Orange, California, United States | Recruiting |
| UCSF Medical Center-Mission Bay | San Francisco, California, United States | Recruiting |
| Children's Hospital Colorado | Aurora, Colorado, United States | Recruiting |
| Children's National Medical Center | Washington D.C., District of Columbia, United States | Recruiting |
| Children's Healthcare of Atlanta - Arthur M Blank Hospital | Atlanta, Georgia, United States | Recruiting |
| Lurie Children's Hospital-Chicago | Chicago, Illinois, United States | Recruiting |
| Riley Hospital for Children | Indianapolis, Indiana, United States | Recruiting |
| Dana-Farber Cancer Institute | Boston, Massachusetts, United States | Recruiting |
| C S Mott Children's Hospital | Ann Arbor, Michigan, United States | Recruiting |
| University of Minnesota/Masonic Cancer Center | Minneapolis, Minnesota, United States | Recruiting |
| Washington University School of Medicine | St Louis, Missouri, United States | Recruiting |
+ 7 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT06247787