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Study identifier: NCT06246916 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Study With Combinations of Anti-LAG-3 and Anti-PD-1 Antibodies in Adult Participants With Advanced or Metastatic Melanoma (Harmony Head-to-Head)

Condition: Melanoma  ·  Sponsor: Regeneron Pharmaceuticals

PhasePhase 3
Planned participants560
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This study is researching an experimental drug called fianlimab (also known as REGN3767), combined with another medication called cemiplimab (also known as REGN2810), called "study drugs". The study is focused on patients with a type of skin cancer known as melanoma. The aim of the study is to see how safe and effective the combination of fianlimab and cemiplimab is in treating melanoma, in comparison with the combination of two medications, relatlimab and nivolumab, commercialized under the brand name Opdualag™ and approved for the treatment of melanoma in adults and children. The study is looking at several other research questions, including: * What side effects may happen from taking the study drugs. * How much study drug is in the blood at different times. * Whether the body makes antibodies against the study drugs (which could make the drug less effective or could lead to side effects)

This description comes directly from the study's public registry record.

Talk to the study team

Clinical Trials Administrator  ·  844-734-6643  ·  clinicaltrials@regeneron.com

Always discuss trial participation with your own doctor first.

Locations (110)

Ironwood Cancer & Research CentersChandler, Arizona, United StatesRecruiting
Banner MD Anderson Cancer CenterGilbert, Arizona, United StatesRecruiting
Arizona Oncology AssociatesTucson, Arizona, United StatesWithdrawn
University of Arkansas for Medical SciencesLittle Rock, Arkansas, United StatesRecruiting
Providence Medical FoundationFullerton, California, United StatesRecruiting
Cancer and Blood Specialty ClinicLos Alamitos, California, United StatesRecruiting
University of California Los AngelesLos Angeles, California, United StatesRecruiting
St. Joseph Hospital OrangeOrange, California, United StatesRecruiting
University of California Irvine, UCI Medical CenterOrange, California, United StatesRecruiting
Eisenhower Medical CenterRancho Mirage, California, United StatesWithdrawn
Emad Ibrahim, MD, Inc.Redlands, California, United StatesRecruiting
Sutter HealthSacramento, California, United StatesRecruiting

+ 98 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06246916