Condition: Metastatic Colorectal Cancer · Metastatic Gastroesophageal Adenocarcinoma · DPD Deficiency · Sponsor: UNICANCER
The goal of this clinical trial is to test the safety of the trifluridine/tipiracil as replacement of fluoropyrimidines based chemotherapy as first line metastatic colorectal or gastroesophageal cancer regimens in patients with dihydropyrimidine dehydrogenase (DPD) deficiency. The main questions it aims to answer are: * Is this alternative chemotherapy option a better option in term of safety for this type of patients? * Does the combination of treatments improves the overall safety? * Does the combination of treatments improves the progression-free survival, overall survival, objective response rate and disease control rate? * Does the combination of treatment have an effect on quality of life? Participants will: * Receive the trifluridine/tipiracil with oxaliplatin every 14 days, associated with: * Panitumumab or bevacizumab for colorectal adenocarcinomas * Nivolumab or trastuzumab for gastroesophageal adenocarcinomas. * Have a CT-Scan every 2 months until disease progression * Complete Health-related quality of life questionnaire every 2 months for a maximum of 6 months * Participate to the optional translational research: Blood samples fo DPYD genotyping and pharmacokinetic analysis
This description comes directly from the study's public registry record.
Emilie BRUMENT · +33(0)6 68 32 03 59 · e-brument@unicancer.fr
Always discuss trial participation with your own doctor first.
| CHU Amiens | Amiens, France | Not Yet Recruiting |
| Institut de Cancérologie de l'Ouest | Angers, France | Not Yet Recruiting |
| Institut du Cancer d'Avignon | Avignon, France | Active Not Recruiting |
| CHU Jean Minjoz | Besançon, France | Active Not Recruiting |
| Centre Hospitalier de Cholet | Cholet, France | Active Not Recruiting |
| Centre Georges François Leclerc | Dijon, France | Withdrawn |
| Hôpital Privé Jean Mermoz | Lyon, France | Active Not Recruiting |
| Institut Régional du Cancer de Montpellier - ICM Val d'Aurelle | Montpellier, France | Recruiting |
| Hôpital Saint Louis | Paris, France | Active Not Recruiting |
| Hôpital Saint Antoine | Paris, France | Recruiting |
| Hôpital Cochin | Paris, France | Active Not Recruiting |
| Hôpital des Diaconesses Croix Saint Simon | Paris, France | Active Not Recruiting |
+ 9 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT06245356