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Study identifier: NCT06245109 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Brain-Based and Clinical Phenotyping of Pain Pharmacotherapy in Knee Osteoarthritis

Condition: Knee Osteoarthritis  ·  Sponsor: Northwestern University

PhasePhase 4
Planned participants180
Who can joinAll sexes, 41 Years to no upper limit
Healthy volunteersNo

About this study

This is a clinical trial of people who have pain due to knee osteoarthritis at Northwestern University Feinberg School of Medicine. The study will last for about 20 weeks. 180 qualified participants will be randomly assigned in a 1:1:1 ratio (60 participants per group) to one of three treatment groups: duloxetine, celecoxib, or placebo. Participants will have a knee Xray, (optional) MRIs of the brain and knee, blood draws, pain sensitivity testing, and asked to fill out questionnaires. The purpose of this study is to try to predict which participants will respond to the treatment.

This description comes directly from the study's public registry record.

Talk to the study team

Graeme Witte  ·  3125034163  ·  graeme.witte@northwestern.edu

Narina Simonian, BS, CCRC  ·  3125035780  ·  n-simonian@northwestern.edu

Always discuss trial participation with your own doctor first.

Locations (1)

Northwestern UniversityChicago, Illinois, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06245109