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Study identifier: NCT06239311 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Efficacy and Safety of Methotrexate Versus Placebo in Adults With Atopic Dermatitis.

Condition: Moderate to Severe Atopic Dermatitis  ·  Sponsor: medac GmbH

PhasePhase 3
Planned participants277
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

Atopic dermatitis is an ongoing condition that causes skin irritation, redness, and itchiness. Treatments are usually topical - applied to the skin (e.g., moisturisers or medicated creams) - but a wider variety of systemic treatments (that target the whole body) are needed for those whose condition does not improve with topical treatments. Methotrexate, a drug approved for similar conditions such as arthritis and psoriasis, has been shown to improve atopic dermatitis. This randomised, controlled clinical trial will investigate how effective.

This description comes directly from the study's public registry record.

Talk to the study team

Medac Clinical Trial Information  ·  +49 (0)4103 8006  ·  ClinicalTrialInformation@medac.de

Always discuss trial participation with your own doctor first.

Locations (30)

MU Dr. Petr Arenberger, DrSc. MBAPrague, Praha 1, CzechiaRecruiting
Synexus Czech s.r.o.Prague, Praha 2, CzechiaTerminated
Praglandia s.r.o.Prague, Praha 5, CzechiaRecruiting
AGE Centrum s.r.o.Olomouc, CzechiaWithdrawn
CCR Ostrava s.r.o,Ostrava, CzechiaRecruiting
CCR Czech Pardubice a.s.Pardubice, CzechiaRecruiting
Clintrial s.r.o.Prague, CzechiaRecruiting
Dermatology clinic MUDr. Blanka HavlickovaPrague, CzechiaRecruiting
Centre Hospitalier Universitaire de Bordeaux - Hopital Saint AndreBordeaux, FranceWithdrawn
Centre Hospitalier universitaire (CHU) de Clermont Ferrand Hopital d'EstaingClermont-Ferrand, FranceWithdrawn
Centre Hospitalier Universitaire De NantesNantes, FranceWithdrawn
Centre Hospitalier Lyon-SudPierre-Bénite, FranceRecruiting

+ 18 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06239311