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Study identifier: NCT06239116 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Study of RM-718 in Healthy Subjects and Patients With MC4R Pathway Impairment

Condition: Hypothalamic Obesity · Prader-Willi Syndrome · PWS  ·  Sponsor: Rhythm Pharmaceuticals, Inc.

PhasePhase 1/Phase 2
Planned participants150
Who can joinAll sexes, 12 Years to 65 Years
Healthy volunteersYes

About this study

The purpose of this study is to evaluate the safety, tolerability, and PK of RM-718 in healthy subjects with obesity and in patients with MC4R Pathway Impairment

This description comes directly from the study's public registry record.

Talk to the study team

Rhythm Clinical Trials  ·  (857) 264-4280  ·  clinicaltrials@rhythmtx.com

Physician Inquiry Clinical Trials  ·  (857) 264-4280  ·  clinicaltrials@rhythmtx.com

Always discuss trial participation with your own doctor first.

Locations (7)

UAB Pediatric Endocrinology (Part C and Part D)Birmingham, Alabama, United StatesRecruiting
Ann and Robert H. Lurie Children's Hospital of Chicago (Part C and Part D)Chicago, Illinois, United StatesRecruiting
Boston Children's Hospital (Part C only)Boston, Massachusetts, United StatesRecruiting
Brigham and Women's Hospital (Part C and Part D)Boston, Massachusetts, United StatesRecruiting
Vanderbilt University Medical Center (Part C only)Nashville, Tennessee, United StatesRecruiting
Worldwide Clinical Trials (Part A and Part B)San Antonio, Texas, United StatesCompleted
University of Utah Pediatric Endocrine Clinic (Part C and Part D)Salt Lake City, Utah, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06239116