Condition: Precursor Cell Lymphoblastic Leukemia-Lymphoma · Sponsor: National Research Center for Hematology, Russia
Non-intensive But Non-interruptive Treatment based on previously study RALL-2016 of Adult Ph-negative Acute Lymphoblastic Leukemia: No high-dose methotrexate (MTX) and high-dose cytarabine (ARA-C) consolidation blocks, L-asparaginaseis scheduled for 1 year of treatment, 21 intrathecal injections through the whole treament, T-ALL patients in complete remission (CR) with MRD-positive status after 2nd induction receive consolidation 1-3 with venetoclax (56 days), and B-ALL patients in complete remission (CR) with MRD-positive status after 2nd induction receive 1 consolidation with blinatumomab. After that consolidation bone samples are collected and tested for MRD and patients will continue therapy by protocol without HSCT if MRD-negative (by flow cytometry by aberrant immunophenotype in a centralized lab) status was achieved.
This description comes directly from the study's public registry record.
Olga Aleshina, MD, PhD · +79629745058 · dr.gavrilina@mail.ru
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| Olga Aleshina | Moscow, Russia | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06237192