Condition: Obesity · Type2diabetes · Lipodystrophy · Sponsor: Federico II University
Obesity is a life-threatening disease, defined by excessive fat accumulation that increases the risk of other diseases such as cardiovascular events, hypertension, diabetes and cancer. Obesity is also a risk factor for nosocomial infections and is associated with worse COVID-19 outcomes, although anthropometric measurements are not routinely recorded during hospitalization and lack of a registry data does not allow performing retrospective studies.Obesity is closely related to chronodisruption, characterized by deregulation of physiological and behavioral central and peripheral circadian rhythms contributing to the obesity-related metabolic impairment. Eating and sleeping time schedules are relevant synchronizers of humans' biological clock. Several studies suggest a role of dietary interventions in rewiring the circadian rhythm, with Mediterranean diet (MD) regulating nutritional patterns. Moreover, considering its positive impact on sleep quality, melatonin intake was suggested as a potential regulator of circadian rhythms. The relation between chronodisruption, obesity and infections has not been investigated, and a first proof of concept (Pilot study) will aim at investigating it. Three cohorts of obese patients with different aetiology (essential obesity, obesity with type 2 diabetes, genetic forms of obesity) and a cohort of lipodystrophic patients will be enrolled in the study, which is designed as a two-phases protocol. During the first phase (0-12 weeks (w)) patients…
This description comes directly from the study's public registry record.
Annamaria Colao, Prof · +393285390000 · colao@unina.it
Always discuss trial participation with your own doctor first.
| "Federico II" University of Naples, Department of Clinical and Molecular Endocrinology and Oncology | Naples, Italy | Recruiting |
| Università del Piemonte Orientale | Novara, Italy | Recruiting |
| University of Pisa | Pisa, Italy | Recruiting |
| "Sapienza" University of Rome | Roma, Italy | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06236932