Condition: Cancer, Rectal · Sponsor: Centre Hospitalier Universitaire de Nīmes
The present study will investigate the safety of inferior mesenteric artery embolization prior to rectal surgery, according to IDEAL recommendations (Lancet 2009). It aims to assess the safety of endovascular embolization of the inferior mesenteric artery prior to surgery in patients with rectal tumors, and estimate the potential benefits in terms of time to surgery and the occurrence of post-operative fistulas.The study will also assess the impact of subacute ischemia induced by IMA embolization on colonic vasculature remodeling, colonic ischemic suffering, altered hemostasis and initiation of neo-angiogenesis through blood sampling kinetics.The hypothesis is that ischemic preconditioning by inferior mesenteric artery embolization prior to rectal cancer resection surgery is safe and will result in a decrease in acute relative colon ischemia and a reduction in the rate of fistulas and post-surgical complications. Indeed, we believe that the beneficial effects of the ischemic preconditioning of IMA will be due to better blood perfusion of the colon at 3 weeks, which is apparently linked to remodeling and/or the development of collateral vascularization.
This description comes directly from the study's public registry record.
Martin BERTRAND, Professor · +336.43.50.35.22 · martin.bertrand@chu-nimes.fr
Anissa MEGZARI · +33466684236 · drc@chu-nimes.fr
Always discuss trial participation with your own doctor first.
| Hôpital Saint-Eloi | Montpellier, France | Recruiting |
| Institut du Cancer de Montpellier | Montpellier, France | Recruiting |
| CHU de Nîmes | Nîmes, France | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06236633