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Study identifier: NCT06234631 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Cannabidiol for Postoperative Opioid Reduction in Primary Total Knee Arthroplasty

Condition: Knee Replacement Surgery · Osteoarthritis, Knee  ·  Sponsor: Chad Brummett

PhasePhase 2
Planned participants380
Who can joinAll sexes, 18 Years to 80 Years
Healthy volunteersNo

About this study

The goal of this study is to better understand how daily treatment with cannabidiol (CBD) affects the need for opioid pain medication, as well as pain, inflammation and other related symptoms, after knee replacement surgery. The information collected in this study is necessary to help understand whether CBD may be a useful medication before and/or after surgery. The study hypothesis is that CBD exerts opioid-sparing effects through anti-inflammatory, analgesic, and anxiolytic mechanisms.

This description comes directly from the study's public registry record.

Talk to the study team

Kendall Dubois  ·  734-232-0324  ·  kendalld@med.umich.edu

Always discuss trial participation with your own doctor first.

Locations (2)

University of MichiganAnn Arbor, Michigan, United StatesRecruiting
Henry Ford Health SystemDetroit, Michigan, United StatesNot Yet Recruiting

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Source record: clinicaltrials.gov/study/NCT06234631