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Study identifier: NCT06233461 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Study on the Safety of TAK-279 and Whether it Can Reduce Inflammation in the Bowel of Participants With Moderately to Severely Active Crohn's Disease

Condition: Crohn's Disease  ·  Sponsor: Takeda

PhasePhase 2
Planned participants268
Who can joinAll sexes, 18 Years to 75 Years
Healthy volunteersNo

About this study

Crohn's disease (CD) is a long-lasting condition causing inflammation that can affect any part of the gut. The purpose of this study is to evaluate the efficacy and safety of TAK-279 versus placebo in participants with moderately to severely active Crohn's disease (CD). The main aim of this study is to learn if the 3 different doses of TAK-279 reduce bowel inflammation and ulcers in the bowel compared to the placebo after 12 weeks of treatment. Another aim is to compare any medical problems that participants have when they take TAK-279 or placebo and how well the participants tolerate medical problems. An endoscopy will be used to check the bowel for inflammation. The participants will be treated with TAK-279 for 52 weeks (1 year). During the study, participants will visit their study clinic 15 times.

This description comes directly from the study's public registry record.

Talk to the study team

Takeda Contact  ·  +1-877-825-3327  ·  medinfoUS@takeda.com

Always discuss trial participation with your own doctor first.

Locations (190)

United Medical DoctorsMurrieta, California, United StatesRecruiting
UCI HealthOrange, California, United StatesRecruiting
West Central Gastroenterology, LLP, d/b/a/ Gastro FloridaClearwater, Florida, United StatesRecruiting
Auzmer ResearchLakeland, Florida, United StatesRecruiting
Wellness Clinical ResearchMiami Lakes, Florida, United StatesRecruiting
GI PROS, Inc.Naples, Florida, United StatesRecruiting
AdventHealth (Florida Hospital) Medical GroupOrlando, Florida, United StatesNot Yet Recruiting
USF Health Morsani Center for Advanced HealthcareTampa, Florida, United StatesRecruiting
Emory University Hospital, The Emory ClinicAtlanta, Georgia, United StatesRecruiting
Atlanta Center For Gastroenterology, P.C.Decatur, Georgia, United StatesRecruiting
The University of Iowa Hospitals & ClinicsIowa City, Iowa, United StatesRecruiting
University of Kansas Medical CenterKansas City, Kansas, United StatesNot Yet Recruiting

+ 178 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT06233461