Condition: Peripheral Artery Disease · Polyvascular Disease · Sponsor: Yonsei University
Patients with atherosclerotic peripheral artery disease often have combined coronary artery disease or cerebral artery disease and show high rates of cardiovascular mortality and morbidities. Therefore, secondary prevention for these patients is of great clinical importance. Currently, Korean, US, and European guidelines recommend different LDL cholesterol target goals in patients with peripheral artery disease. In recent clinical trials, combination therapy of statin plus ezetimibe demonstrated improved cardiovascular outcomes compared with statin monotherapy. Thus, the purpose of the CARE-PVD study is to investigate whether the combination therapy of high intensity rosuvastatin 20 mg plus ezetimibe 10 mg can improve cardiovascular outcomes in patient with peripheral artery disease or polyvascular artery disease in comparison with rosuvastatin treat-to-target (LDL cholesterol \<70 mg/dL) monotherapy.
This description comes directly from the study's public registry record.
Young-Guk Ko, MD, PhD · 02)-2228-8460 · ygko@yuhs.ac
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| Division of Cardiology, Yonsei Cardiovascular Hospital, Yonsei University College of Medicine | Seoul, South Korea | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06231966