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Study identifier: NCT06229678 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Ketones, SGLT2, HFrEF

Condition: Type2diabetes · Heart Failure With Reduced Ejection Fraction  ·  Sponsor: The University of Texas Health Science Center at San Antonio

PhaseEARLY_Phase 1
Planned participants71
Who can joinAll sexes, 18 Years to 70 Years
Healthy volunteersNo

About this study

The study team will examine the effects of elevated plasma ketone levels following initiation of SGLT2 inhibitor therapy in high-risk type 2 diabetes mellitus (T2DM) individuals with heart failure (HF) with reduced ejection fraction (HFrEF) providing an energy-rich fuel that is taken up with great avidity by the myocardium, to measure change in Left Ventricle diastolic and systolic function

This description comes directly from the study's public registry record.

Talk to the study team

Ralph DeFronzo, MD  ·  210-567-6691  ·  defronzo@uthscsa.edu

Sivaram Neppala, MD  ·  210-358-7200  ·  neppalas@uthscsa.edu

Always discuss trial participation with your own doctor first.

Locations (1)

Texas Diabetes Institute - University Health SystemSan Antonio, Texas, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06229678