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Study identifier: NCT06228924 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Open-label, Dose Escalation Study of Safety and Preliminary Efficacy of TN-401 in Adults With PKP2 Mutation-associated ARVC

Condition: Arrhythmogenic Right Ventricular Cardiomyopathy  ·  Sponsor: Tenaya Therapeutics

PhasePhase 1
Planned participants15
Who can joinAll sexes, 18 Years to 65 Years
Healthy volunteersNo

About this study

This first-in-human study is designed to evaluate the safety, and preliminary efficacy (PD) of TN-401 gene therapy in adult patients with symptomatic PKP2 mutation-associated ARVC.

This description comes directly from the study's public registry record.

Talk to the study team

Matthew Pollman, M.D.  ·  (650) 416-1186  ·  mpollman@tenayathera.com

Niha Kamat  ·  clinical.trials@tenayathera.com

Always discuss trial participation with your own doctor first.

Locations (7)

University of California San FranciscoSan Francisco, California, United StatesRecruiting
University of Colorado - Anschutz Medical CampusAurora, Colorado, United StatesRecruiting
Johns Hopkins UniversityBaltimore, Maryland, United StatesRecruiting
Brigham and Women's HospitalBoston, Massachusetts, United StatesRecruiting
Mayo ClinicRochester, Minnesota, United StatesRecruiting
NYU Langone HealthNew York, New York, United StatesRecruiting
Cleveland ClinicCleveland, Ohio, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06228924