Condition: Crohn's Disease · Sponsor: Takeda
The main aim of this study is to learn whether vedolizumab and upadacitinib given together (also called dual targeted therapy or DTT) reduces bowel inflammation and ulcers in the bowel compared to vedolizumab only (also called monotherapy) in adults with moderately or severely active Crohn's Disease (CD) after 12 weeks of treatment. Other aims are to learn how safe and effective DTT is compared to monotherapy for these participants. All participants will receive DTT (either vedolizumab and upadacitinib or vedolizumab and placebo) for 12 weeks. Participants responding to the treatment will then receive vedolizumab only (monotherapy) for an additional 40 weeks. During the study, participants will visit their study clinic 15 times.
This description comes directly from the study's public registry record.
Takeda Contact · +1-877-825-3327 · medinfoUS@takeda.com
Always discuss trial participation with your own doctor first.
| UCSD Medical Center | La Jolla, California, United States | Not Yet Recruiting |
| Keck Medicine Of USC - USC Healthcare Center 1 | Los Angeles, California, United States | Not Yet Recruiting |
| Peak Gastroenterology Associates | Colorado Springs, Colorado, United States | Recruiting |
| GI PROS, Inc. | Naples, Florida, United States | Active Not Recruiting |
| Orlando Health Ambulatory Care Center | Orlando, Florida, United States | Active Not Recruiting |
| USF Health Morsani Center for Advanced Healthcare | Tampa, Florida, United States | Active Not Recruiting |
| Indiana University (IU) Health University Hospital | Indianapolis, Indiana, United States | Active Not Recruiting |
| University of Kentucky | Lexington, Kentucky, United States | Active Not Recruiting |
| Mount Sinai Hospital - The Susan and Leonard Feinstein Inflammatory Bowel Disease (IBD) Clinical Center | New York, New York, United States | Active Not Recruiting |
| Columbia University Medical Center, New York-Presbyterian Hospital | New York, New York, United States | Not Yet Recruiting |
| Lenox Hill Hospital Northwell Health | New York, New York, United States | Active Not Recruiting |
| Gastroenterology Associates | Greenville, South Carolina, United States | Active Not Recruiting |
+ 126 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT06227910