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Study identifier: NCT06225843 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Sotevtamab (AB-16B5) Combined With FOLFOX as Neoadjuvant Treatment Prior to Resection of Colorectal Cancer Liver Metastasis

Condition: Metastatic Colorectal Cancer  ·  Sponsor: Alethia Biotherapeutics

PhasePhase 2
Planned participants17
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This Phase II study will recruit 17 colorectal cancer patients with liver-dominant metastases. All recruited patients will receive Sotevtamab at a dose of 800 mg once weekly for 6 cycles combined with FOLFOX once every 2 weeks for the first 4 cycles followed by liver metastases resection surgery with or without primary cancer resection. One cycle of treatment will consist of 14 days (2 weeks).

This description comes directly from the study's public registry record.

Talk to the study team

Julie Laurin, B. Pharm, Ph.D.  ·  514-581-8125  ·  julie.laurin@alethiabio.com

Always discuss trial participation with your own doctor first.

Locations (1)

Centre Hospitalier de l'Université de Montréal (CHUM)Montreal, Quebec, CanadaRecruiting

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Source record: clinicaltrials.gov/study/NCT06225843