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Study identifier: NCT06225570 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Weekly Isotretinoin vs Tetracycline for Moderate Acne

Condition: Acne Vulgaris  ·  Sponsor: Medical University of South Carolina

PhaseEARLY_Phase 1
Planned participants50
Who can joinAll sexes, 12 Years to no upper limit
Healthy volunteersYes

About this study

In the effort to find better treatments for Moderate Acne, which often relies on long-term antibiotic use, researchers are exploring alternative options. While Isotretinoin, a Vitamin A derivative, is highly effective for severe acne, its side effects limit its use for milder cases. A recent study from our institution investigated a new approach: weekly Isotretinoin dosing. The results were promising, with acne improvement and no major side effects. This suggests that weekly Isotretinoin could be a successful alternative for moderate acne in both males and females. To validate these findings, investigators propose a randomized controlled trial comparing weekly Isotretinoin to daily Doxycycline over four months. This study could confirm the safety and effectiveness of weekly Isotretinoin, as well as shed light on patient satisfaction, and long-term results compared to standard antibiotics. This research may offer a breakthrough in treating moderate acne while addressing concerns about antibiotic overuse.

This description comes directly from the study's public registry record.

Talk to the study team

Kathryn Keller, BS  ·  8646301689  ·  kellerka@musc.edu

Always discuss trial participation with your own doctor first.

Locations (1)

Medical University of South CarolinaCharleston, South Carolina, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06225570