Condition: Asthma · Sponsor: Copenhagen University Hospital, Hvidovre
This observational longitudinal cohort study aims to assess the effect of monoclonal antibodies targeting interleukin 17 (anti-IL-17) on airway hyperreactivity and airway resistance. The study involves adult participants suffering from dermatological or rheumatological illness, who are planning to start treatment with monoclonal antibodies targeting interleukin 17 as a part of the treatment of these diseases. The primary outcome of this study will be changes in airway hyperresponsiveness to methacholine challenge reported as response-dose-ratio before and after initiation of anti-IL17 treatment regardless of presence of respiratory disease. Furthermore, the potential effect of anti-IL-17 on airway resistance will be assessed using conventional spirometry for measuring changes in FEV1 and Airwave oscillometry. A reduced degree of airway hyperreactivity and airway resistance after initiating ani-IL-17 could indicate effectiveness of anti-IL-17 in asthma patients which would have to be examined further in a population of asthma patients.
This description comes directly from the study's public registry record.
Jonas A Baekdal, MD · +45 60134687 · jonas.aggerholm.baekdal.02@regionh.dk
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| Respiratory Research Unit Hvidovre Department of Respiratory Medicine, Copenhagen University Hospital | Hvidovre, Capital Region, Denmark | Recruiting |
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Source record: clinicaltrials.gov/study/NCT06224634