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Study identifier: NCT06220656 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

TRAIL Study: Feasibility and Pilot

Condition: Thyroid Nodule · Thyroid Neoplasms · Thyroid Cancer  ·  Sponsor: Dartmouth-Hitchcock Medical Center

PhaseNA
Planned participants20
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This is a pilot study to compare two ways of managing newly identified thyroid nodules that are likely to be cancerous based on ultrasound result and which under usual care would undergo immediate biopsy. The main goals of this pilot study are 1) compare anxiety at 6 months in each treatment arm using the validated instrument Anxiety-CA, 2) measure thyroid quality of life in each treatment arm Participants will be randomized to one of two groups: 1. immediate biopsy (usual care) 2. Active monitoring (serial ultrasound based monitoring and close clinical follow-up)

This description comes directly from the study's public registry record.

Talk to the study team

Michaela M Geffert, BS  ·  (603) 305-3529  ·  michaela.m.geffert@hitchcock.org

Always discuss trial participation with your own doctor first.

Locations (1)

Dartmouth Hitchcock Medical CenterLebanon, New Hampshire, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT06220656